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Moreover, the synergistic effect of AMPK and SIRT1 significantly enhances fatty acid oxidative metabolism, increasing cellular energy utilization efficiency (23, 53)

Acknowledgements We acknowledge BioRender ( to produce some materials in the figures

Therefore, one set of preferred useful combinations include GSH and drugs intended to treat chronic conditions which are well absorbed on an empty stomach, and do not have adverse interactions or reduced or variable combined absorption

RNA-Seq Analyses Biological duplicates of RNA-seq on human monocytes untreated or stimulated with BDG for 1 hour, 4 hours, or 24 hours were downloaded using the SRA toolkit using fastq-dump (GEO: GSE85246)