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Pharmacol Res 175:106029

Xenobiotica 28 , 443456 (1998)

liraglutide improved metabolic parameters such as body weight, dysglycemia, and insulin resistance, which was consistent with previous study ( in vitro ) or intestinal L cells in type 2 diabetic rats and human ( in vivo ) with exendin-4 or liraglutide treatment ( A growing body of evidence has shown that chronic low-grade inflammation plays a critical role in prediabetes and diabetes ( The gut microbiota and its metabolites play critical roles in regulating host metabolism, immune function, insulin resistance and overall health ( We observed that liraglutide treatment led to 224 differentially abundant metabolites in prediabetic mice compared with control mice, 96 metabolites of which showed significantly increased abundances, whereas those of 128 metabolites were decreased