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Now, what too much and too little are I think remains to be seen

**Ketamine troches** are easier to use at home and may provide longer-lasting effects per dose, but their lower bioavailability means less of the drug reaches the brain, and current research suggests their antidepressant effect may be milder or less reliable than IV or IM routes[2][5]

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Given that mitochondrial dysfunction is linked to LLD, the role of vitamin B5 in supporting mitochondrial function may offer a therapeutic avenue to alleviate depressive symptoms in older adults