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Polysaccharide A (PSA) from Bacteroides fragilis can induce the expansion of CD4+T cells systemically and reverses the Th1 /Th2 imbalance, and exerts systemic anti-inflammatory activities by enhancing the production of IL-10 and by promoting the level and function of IL-10+Foxp3+Treg cells [61,62,63]

Abbreviations FDA: The US Food and Drug Administration EMA: European Medicines Agency SCS: Subcapsular sinus APCs: Antigen-presenting cells DDAB: Dimethyl dioctadecyl ammonium bromide TDB: Trehalose-6,6-dibehenate TLR: Toll-like receptor PolyIC: Polyinosinic-polycytidylic acid T-MP: Curcumin-loaded porphyrin micelles HSA: Human serum albumin MSNs: Mesoporous silica nanoparticles MSRs: Mesoporous silica rods PEI: Polyethyleneimine aMT-exos: A hybrid exosomes AIDS: Acquired immunodeficiency syndrome RES: Reticuloendothelial system CRGDY: Cyclic arginine-glycine-aspartate peptide References Kase AM, Menke D, Tan W

Importantly, this kind of training must be performed safely in a controlled environment where the patient can be confident that they can move without fear of falling (Ozkul et al., 2020