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doi: 10.1056/NEJMoa0907118

doi: 10.1016/j.freeradbiomed.2014.06.010 188 MaFWuJJiangZHuangWJiaYSunWet al

Nat Commun 16 , 10474 (2025)

Immunogenicity and safety Immunogenic responses to viral vectors, recombinant proteins, or sustained NTFs overexpression pose a significant, though often underdiscussed, translational risk