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doi: 10.1016/j.mito.2017.08.002 97 GeY

Here, using a metabolic-scale CRISPR activation screen integrated with transcriptomic and metabolomic analyses, we identify L-2-hydroxyglutarate dehydrogenase (L2HGDH) as a potent antagonist of ferroptosis in HCC

Julius, M., Lang, C

These unresolved problems highlight an unmet clinical need for new drugs that are effective and safe, to achieve full remission of symptoms and better mood-stabilization [11]