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When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Figure 2)

They were exposed to continuous light during the dark cycle (18:00 to 06:00) for the entire experimental period

We adhere steadfastly to all regulatory guidelines without compromise

Immune response modulation by vitamin D: role in systemic lupus erythematosus