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The thyroid hormone plays a vital role in many bodily functions, including the regulation of metabolism, heart rate, body temperature, and energy levels

Tazemetostat, an oral EZH2 inhibitor, is approved for treating epithelioid sarcoma, and is under investigation for other cancers [188]

Further studies have established that APR-246 can also trigger p53-independent cell death in several solid cancers, suggesting that besides p53, other cellular targets might be involved in APR-246 effect [56]