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Firstly, the Xc system (solute carrier family 7 member 11 and family 3 member 2 (SLC7A11 and SLC3A2)) is responsible for taking up cystine to generate the substrate cysteine for the synthesis of GSH and is also involved in the formation of the GPX4 catalytic unit

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Results VRK2-deficient PC cells are vulnerable to GSH inhibition To investigate the impact of VRK2 on metabolic reprogramming, we treated VRK2-wild-type (VRK2-WT) and VRK2-knockout (VRK2-KO) CFPAC-1 cell lines with 281 metabolism compounds (Supplementary Table1)