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8 Conclusions and future perspectives Since the levels of inflammatory cytokines as well as increased oxidative stress are related to cachexia, therapeutic strategies to ameliorate such conditions may be extremely important to counteract these deleterious effects

Glutamine deprivation impairs severe metabolism reprogramming in a poorly differentiated cell line, which results in kinase inhibitors resistance as increased phosphorylation of extracellular signal-regulated kinase (Nwosu et al., 2020)

INO-1001 subcutaneous administration has also proven effective in attenuating oxidative stress (reduced MDA levels), inflammation (reduced expression of Tnf- ) and fibrosis in the context of diabetic disease [137]

Beginners and females rarely use the drug due to possible negative consequences for health