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BAT CoQ deficiency results in cytosolic accumulation of mitochondrial RNA, leading to PKR activation, ATF4 induction and, as a result, UCP1 suppression

Then, articles were scanned and the data from these studies was extracted, including the number of patients per arm, L-carnitine dosing (including initial loading dosing and daily oral maintenance dosing), acute MI (AMI) index event type, follow-up duration, and outcomes (i.e., all-cause mortality, adverse cardiovascular events including unstable angina, acute MI, heart failure, and ventricular arrythmia)

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(PubMed) Ahsan H, Ahad A, Iqbal J, Siddiqui WA