For example, mitochondrial dysfunction destabilizes lysosomes, amplifying oxidative stress ( 2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis ( 2.2.3 Lysosomes: controllers of iron homeostasis Lysosomes regulate cellular debris degradation, biomolecule recycling, and iron metabolismall of which influence ferroptosis ( 2.2.4 Lipid droplets: sources of polyunsaturated fatty acids Lipid droplets (LDs) are dynamic organelles serving as storage reservoirs for neutral lipids, playing pivotal roles in cellular energy homeostasis and lipid metabolism ( 2.2.5 Peroxisomes: modulators of lipid oxidation and antioxidant defense Peroxisomes regulate lipid metabolism and ROS detoxification, influencing ferroptosis ( 2.2.6 Golgi apparatus: regulatory mechanisms in ferroptosis The Golgi apparatus is a vital organelle involved in the post-translational modification, sorting, and trafficking of proteins and lipids within the cell ( Collectively, the dysfunction of key organellesincluding mitochondria, endoplasmic reticulum, lysosomes, lipid droplets, peroxisomes, and the Golgi apparatussynergistically amplifies ferroptosis susceptibility in COPD
Rapid determination of folic acid and riboflavin in urine by polypyrrole magnetic solid-phase extractant combined ultra-performance liquid chromatography
Clinical Journal of Sports Medicine 22(2) :172-208
PNAS 103:56085613 Delaunay A, Pflieger D, Barrault MB, Vinh J, Toledano MB (2002) A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation
