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In vitro and animal studies in vivo have demonstrated the mechanisms of action of AGE, which involve its antioxidant, anti-inflammatory and modulatory effects on neurotransmitter function in the brain regions that are associated with the pathogenesis of AD

Specifically, these problems are highlighted when targeting cytokine pathways

The efficiency of the immune defenses in the respiratory tract is evidenced by the relatively small number of infectious diseases a healthy human has in a lifetime

Surface modification methods, such as PEGylation or acetylation, are being used to balance bioactivity with biocompatibility to control these effects