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Injections can cause minor effects such as irritation or itching at the injection site, and the consumer fact sheet is a good plain-language reference on what B12 does and does not do

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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018