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Salvianic acid A, the active ingredient of traditional Chinese medicine, can down-regulate the expression of inflammatory factors by inhibiting NF-B/HIF-1 and HIF-1/STAT3/NLRP3 signaling pathways, inhibit cell excessive proliferation, and improve hypoxia-induced FLS injury (154)

Cutolo M, Nikiphorou E

Together, these findings suggest that checkpoint activation could indirectly influence ferroptosis-associated pathways in AD, yet the connection remains inferential, underscoring the need for future multi-omics and spatial single-cell studies in human brains to validate this link

Problematic detoxification of Estrogen Quinones by Nad(P)H-dependent Quinone Oxidoreductase and glutathione-S-Transferase