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middle school (grades 68) and high school (grades 912) students that focuses exclusively on tobacco product use and associated factors and remains critical to informing FDAs tobacco regulatory activities in the United States

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3 On average, smokers die 10 years earlier than nonsmokers

Nicotine (absorbed into the blood through the vapour produced by the ENDS) is likely to only enter the brain between 5 and 20 seconds after each inhalation 11 , and modelling this effect within a conventional fMRI design would be difficult, since the timing of the nicotine hit after each trial is somewhat uncertain