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USP7 inhibitors, such as P5091 and P22077, selectively ablated senescent cells by upregulating p53 (71)

Side Effects and Safety Reported Side Effects (Rare) Mild headache (transient, first dose) Slight injection site irritation Nausea (if dosed too high on empty stomach) Sleep quality changes (usually improvement) Safety Profile Non-hormonal doesn't suppress testosterone or disrupt hormonal systems No major contraindications known No overdose risk excess peptide is simply cleared Well-tolerated across diverse populations No organ toxicity safe for liver, kidney, heart Contraindications (Caution) Active cancer growth-promoting effects could theoretically benefit cancer (no direct evidence, but be cautious) Pregnancy insufficient human data Active infection at injection site standard sterile injection protocols apply Drug Interactions No known major interactions with common medications

In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)