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Funding This work was supported by the National Heart, Lung, and Blood Institute (R01 HL112212 to DEL), the National Institute on Drug Abuse (K01 DA042687 to KPR, R01 DA050482 to KPR, and R01 DA054935 to DEL), and the National Institute on Aging (R01 AG069575 to EPH) of the National Institutes of Health, the Agency for Healthcare Research and Quality (T32HS000063 to JEB), and the American Lung Association (Innovation Award IA-834584 to KPR)

This article is part of the special issue on Impact of lifestyle and behavioral risk factors on endothelial function and vascular biology in Pflgers ArchivEuropean Journal of Physiology Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Funding G.M.J.T