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Dimensions: 6000 x 4000 px | 50.8 x 33.9 cm | 20 x 13.3 inches | 300dpi Date taken: 7 February 2017 Location: United States

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Screening with low-dose CT scans reduces lung cancer mortality among individuals with high a priori risk, but only marginally among those at lowest risk.20 Therefore, several algorithms, which include self-reported smoking have recently been developed to predict smokers' risk of lung cancer.21 ,22 Measurement of AHRR methylation extent might, therefore, provide valuable information beyond that of existing risk prediction models identifying individuals eligible for CT scan lung cancer screening, for example the 6-year predicted risk algorithm (PLCO M2012 ) from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.22 We aimed to test the hypothesis that AHRR (cg05575921) hypomethylation is associated with the risk of smoking-related morbidity and mortality in the general population