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507 The brains of individuals with preclinical AD (PCAD) and AD exhibit oxidative damage to a variety of molecules, e.g., accumulation of protein carbonyls (PCs) in regions that are rich in A-peptide-containing SPs, increased lipid peroxidation in AD and PCAD hippocampi and elevated DNA damage

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According to Fairfax, the clinical trial showed participants reported 118 adverse events, three deemed severe

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Further experimental studies and clinical trials are now necessary to document the relative importance of the oxidant stress caused by an altered redox potential associated with an elevation of homocysteine level, in comparison with alternative molecular mechanisms

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