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DNA primase is crucial for initiating DNA replication and synthesizing Okazaki fragments during the synthesis of lagging strand (Shiratori et al., 1995

Discovery [edit] GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it was described as an enzyme capable of protecting against peroxidation

Other Articles Reynolds A, Ravandi-Kashani F, Medeiros L, Kornblau SM , Jabbour EJ, Jain N, Short NJ, Hu S, Wei Q, Loghavi S, Ok CY, Toruner G, Ling J, Liang S, Verma T, Zou YS, Wang SA Comprehensive Cytogenomic Profiling of T-Lymphoblastic Leukemia by Optical Genome Mapping and Next Generation Sequencing

Exogenous pyruvate can thus at least partially bypass the GOT1/2 defect and restore proliferation both in vitro and in vivo