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Furthermore, there is a linear relationship between exercise-induced ROS accumulation and Nrf2 activation [15], which is dependent on the duration of the exercise bout [15, 16]

Ameliorated motor neuron degeneration in SOD1 G93A GPX4 double transgenic mice We next compared motor neuron degeneration between SOD1 G93A and SOD1 G93A GPX4 mice