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While utilization of a cross-over design is not always feasible, it reduces the element of variability within a participant and subsequently, increases the strength of studys findings

doi:10.1007/s10555-019-09815-3 Pagana, Kathleen Deska, et al

doi:10.1007/s00405-012-2179-0 144

(1992) published foundational work in the Journal of Molecular Endocrinology characterizing Long R3 IGF-1's enhanced potency in cell proliferation assays compared to native IGF-1