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Pharmacophore modeling, a critical 3D feature of the chemical structure of UA, is instrumental in defining its probable targets

10.1016/j.fertnstert.2023.11.026 45 ZiniA.BomanJ

Vitamin C may indirectly assist in minimizing oxidative stress associated with chronic stress by maintaining adrenal health and normalizing cortisol levels (100)

Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)