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10.1016/j.dsx.2020.05.022 216 RudnickaL.GlowackaP.GoldustM.SikoraM.Sar-PomianM.RokowskaA.et al (2020)

The only reason to think about washouts is at very aggressive daily doses, and even then its an enzyme-economy issue rather than a receptor issue

This powerful antioxidant works by inhibiting tyrosinase, the enzyme responsible for melanin production, thereby reducing hyperpigmentation and promoting a more even skin tone