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For a patient with a highly sensitized immune system or a CIRS diagnosis, achieving a very low HERTSMI-2 score is critical before they can safely occupy a space without triggering a severe inflammatory relapse

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Although this mechanism remains hypothetical, studies on xCT-knockout mice, which are unable to export cellular Glu in exchange for extracellular cystine, suggest a reduction in excitotoxicity [45,164] and indirectly support this hypothetical mechanism

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