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Given that self-derived signals primarily drive it, the term auto-aging is proposed to describe the accelerated aging mediated by NLRP3 in the broader population

Moreover, we further identified P300 as the main succinylation-catalyzing enzyme of GCLC, and their association showed a remarkable decrease upon ROS treatment

2007), transient receptor potential channels (TRPC) (Vohra et al

The downregulation of SIRT1 diminishes the inhibitory effect of vitamin K-2 (VK2) on ferroptosis in BMSCs exposed to high glucose, consequently contributing to bone loss ( 2.4 The relationship between ferroptosis and different clinical subtypes of osteoporosis The clinical subtypes of osteoporosis primarily include postmenopausal osteoporosis, diabetic osteoporosis, glucocorticoid-induced osteoporosis, and thalassemia-related osteoporosis