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Fibromyalgia and irritable bowel syndrome (IBS) are examples of frequently co-existing nociplastic pain conditions that are typically associated with symptoms such as disturbed sleep, fatigue, cognitive dysfunction, depression, and anxiety 4,5,6

Caffeines antagonistic effect against adenosine receptors prevents adenosine-dependent vasodilatation and increases adenosine concentrations

They support granulosa cell function in ovaries and Sertoli cell support in testes and can improve the local environment for gamete development

These can then feed into a variety of biosynthetic pathways for elongations and other modifications