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Barger et al

CYP2E1 oxidation generates reactive oxygen species (ROS) as byproducts

Utilizing high-throughput measurement methods applied to the novel, more accurate and appropriate model systems will provide valuable data for the development of GSH metabolism and interaction models both as mechanistic, knowledge-based or machine-learning, data-based models providing platforms for drug target determination and investigation of complete effect of combined therapies

The flys nervous system shares significant functional and structural similarities with mammals, making it an ideal model for studying the molecular pathways underlying AD pathology