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Because folate supplementation can efficiently reduce plasma homocysteine levels, both in the fasting state and after methionine loading, results from further prospective cohort studies and from on-going interventional trials will determine whether homocysteine-lowering therapies can contribute to the prevention and reduction of cardiovascular risk

The largest concentration is found in offal (liver in particular) and then continues to decrease through lean meat to dairy products

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However, controlled combination studies with clear statistical endpoints are rare, so synergistic effects remain largely hypothetical at present