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58 The Journal of American Folklore , 78 (308): 99114, doi:10.2307/538277, JSTOR 538277 "Tools of the Trade, Tobacco smoke enemas", The Lancet , 359 (9315): 1442, doi:10.1016/S0140-6736(02)08339-3, S2CID 54371569, retrieved 2008-11-27 Provincial Medical & Surgical Journal , vol

In a randomized, double-blind, placebo-controlled study topiramate has shown gender-specific effects, men were approximately four times more likely to quit smoking when treated with topiramate as compared to placebo [95]

Its expansion into pharmaceuticals may be most worrisome

Similarly to cocaine, it floods the brain with high levels of dopamine that cause users to continue seeking the effects