Upon insulin or growth factor stimulation, increased levels of PtdIns(3,4,5)P compete with the mTOR kinase domain for binding to the pleckstrin homology (PH) domain of SIN1
Tobramycin acts as a bactericidal drug by irreversibly binding to the 30S bacterial ribosome, thus inhibiting protein synthesis (Heijerman et al., 2009)
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