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If your goal is maximum total weight loss and you have significant weight to lose (30+ pounds), GLP-1 agonists deliver the largest magnitude of change

It binds to specific strychnine-sensitive glycine receptors (GlyRs), opening chloride ion channels that allow negatively charged ions to flood into the neuron, thereby hyperpolarizing it

Ipamorelin works through a different receptor (GHS-R1a, the ghrelin receptor) and is selective: it does not materially raise cortisol, prolactin, or aldosterone in research models

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