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Name: when to dose igf-1 lr3 in Aesthetic and Anti-Aging Medicine: Benefits and Risks Recombinant Human IGF-1 LR3 (carrier-free),
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PLoS Biology , 19 (12), e3001480

Strictly defined time-period of interest : covariate layers need to match the distribution of O&M's in the time domain, i.e., there needs to be enough training points spread across the period of interest (in this case 20002022+)

Cancer Res 48:59375940 Brady JF, Ishizaki H, Fukuto JM, Lin MC, Fadel A, Gapac JM, Yang CS (1991) Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites