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For instance, oxidative stress disrupts redox-sensitive organelles, including the endoplasmic reticulum (ER) [9], leading to the accumulation of misfolded proteins, which triggers ER stress and impairs protein folding, modification, and transport [10]

and products produced by recombinant techniques from a prokaryotic or eukaryotic host, including, for example, bacterial, yeast, higher plant, insect, and mammalian cells