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For both positively and negatively associated metabolite sets, the probability of the observed overlap between the associated metabolites within the same KEGG pathway or subpathway and the total set of measured metabolites was determined using Fishers exact test based on the hypergeometric distribution 111

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By measuring the -oxidation of [1- 14 C] palmitate in the mitochondria or peroxisome of the liver or muscle, the present study first indicated that dietary L-carnitine supplementation mainly increased mitochondrial FA -oxidation activity, but not peroxisomal activity, at least in zebrafish