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The oxygen-utilizing patterns were found similar in cold or warm acclimated fishes

Current medicinal chemistry , 19 1, 126-32

This suggestion was supported by the decrease in TAp73 in p53 wt,mut melanoma cells in the absence of any effect on p53 null cells that were devoid of Np73 (Figure 8), and the observation that TAp73 appeared to promote its own turnover as well as that of other p73 forms, including the Np73 in a transactivation-dependent manner

However, in the pathological mechanism of CALD, oxidative stress works as an early injury to trigger neuroinflammation under certain conditions, which lead to severe demyelination and brain damage, resulting in neurodegeneration at last