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Description

In addition, receptors for ACTH (MC2R) are present in normal corticotrophs, allowing ultra-fast feedback regulation of the HPA axis (212)

Circadian Rhythm In parallel with cortisol, ACTH levels vary in an endogenous circadian rhythm, reaching a peak between 06.00-09.00h, declining through the day to a nadir between 23.00h-02.00h, and beginning to rise again at about 02.00-03.00h