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The results have shown that perioperative administration of N-acetylcysteine, selenium, and vitamin C is not effective in preventing acute kidney injury following bypass surgery

Glutathione stands as a crucial and highly efficient endogenous antioxidant within the body

In the core, a necrotic nucleus forms due to the prolonged lack of oxygen and nutrients

In this review, we will discuss the biological basis and preclinical and clinical evidence for NAC as a neurotherapeutic in TBI, the biologic basis for combination therapy with probenecid, and provide a rationale for further investigation of probenecid and NAC combination therapy for TBI