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Because the ADC strands are design to preferentially hybridize with cellular miRNAs, the encapsulated siRNAs are released from core/shell nanoparticles into the nucleoplasm owing to strand displacement reactions (step V) and enter the RNAi pathway, knocking-down the expression of tumor-promoting genes

Cardiac metabolism, reprogramming, and diseases

FIGURE 2 Epigenetic modifications in key genes related to stress and immunity, such as nuclear receptor subfamily three group C member 1 (NR3C1), TNF, and nuclear factor kappa B (NF-B), modulate both the negative feedback of the HPA axis and inflammatory pathways mediated by NF-B, suggesting a link between endocrine dysregulation and immune activation (Palma-Gudiel et al., 2021)

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