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In the field of delivery technology, targeting the unique joint anatomy and pathological environment of OA, developing biodegradable sustained-release carriers such as smart responsive nanogels, porous microspheres, or tissue engineering scaffolds is key to achieving long-term and controlled release of GPX4 genes, regulatory miRNAs or ASOs, or small molecule ferroptosis inhibitors at the lesion site (Wang Y

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doi:10.1074/jbc.R114.563148 ^ Liu H., Wang S., Wang J., Guo X., Song Y., Fu K., Gao Z., Liu D., He W., Yang L.L