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The Loading Phase: Refilling the Tank When you have pernicious anemia caused by autoimmune gastritis, your immune system has destroyed the stomach cells that produce intrinsic factor a protein necessary for absorbing vitamin B12 from food

NEWS Correction 06 January 2026 Update 08 January 2026 2025 FDA approvals Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 17.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 169.00 per year only 14.08 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature Reviews Drug Discovery 25 , 81-87 (2026) doi: Updates & Corrections Correction 06 January 2026 : The brand names of Nuvaxovid and Mnexspike have been corrected in Table 2

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Once your bodys performance begins to drop again, we recommend coming in for another B12 shot in Vienna so you can maintain your results