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3 Given their vasodilatory effect, they relax the involuntary muscles of the vasculature, causing facial flushing, warm sensations, hypotension, tachycardia, lightheadedness and headache

Oxidative denaturation of hemoglobin leads to the release of hemin into the RBC membrane and the released hemin is capable of oxidizing membrane proteins via a thiyl radical intermediate

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In a recent study, In summary, there is growing evidence implicating oxidative stress in the pathogenesis of PH in pre-clinical and clinical studies