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These results demonstrate that TSZW enhances the antioxidant defense capacity of the liver and brain by activating the Nrf2/ARE pathway and suppressing the expression of senescence-associated proteins (p16, p21, p53), thereby reversing the decline in organ function driven by oxidative damage

Proc Natl Acad Sci USA 108 (27): 1112111126

In fact, researchers suspect vagus nerve activation, by way of their focus on deep breathing, helps explain why meditation and yoga are so beneficial, because they often incorporate deep breathing to lower blood pressure and decrease heart rate