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208 An open crossover trial in 22 subjects with fibromyalgia found 200 mg of CoQ10 (as ubiquinone) twice daily (in a supplement that also contained vitamins B2, B6, B9, B12, and E) for three months reduced pain, fatigue, and sleep disturbance compared with no treatment

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Therefore, clinicians should start low and go slow and carefully weigh the sleep benefits of the medication with the potential for cognitive impairment