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The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds

Pinese and colleagues delivered siRNA/MSN-PEI using electrospun scaffolds and demonstrated long-term siRNA availability ( in vivo and produced quantifiable target gene silencing, providing a delivery mode that better matches the continuous seedingcontinuous immunosuppression trajectory of peritoneal metastasis

Integration of snRNA and snATAC datasets predicted the transcription factor-gene regulation network To understand the transcriptomic regulation of genes, we performed snATAC-seq and captured the chromatin accessibility profile of individual liver cells

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