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In case of TCN1 polymorphisms, severe B12 deficiency at tissue level can occur, which can also lead to megaloblastic anaemia, growth retardation, and neurological complications whereas TCN2 mutations are associated with Alzheiners disease and autoimmune gastritis (inflamed stomach lining)

As the global population ages, the incidence of PD is expected to rise, underscoring the crucial need for ongoing research to identify its risk factors (Kouli et al