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In Control cells, nutlin-3 treatment resulted in down-regulation of 2,714 genes and up-regulation of 2,429 genes (Fig 3A)

"Poor metabolizers," however, appear to totally lack the stereospecific (S)-mephenytoin hydroxylase activity, so both (S)- and (R)-mephenytoin enantiomers are N-demethylated to nirvanol, which accumulates in much higher concentrations

There are two distinct AG129 mouse models, the lethal and the non-lethal mouse model

Despite its name, pinealon is not derived from the pineal gland, but rather from a ground-up brain extract called cortexin, which is specific to the cortical region of the brain, not the subcortical regions 4m30s