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Using T cell leukemia as a model, we confirmed that the canonical CD39/CD73 pathway is flanked by another set of surface molecules leading to the production of ADO, but using NAD + as a leading substrate ( + -glycohydrolase/CD38, the ectonucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)/CD203a and the 5-ectonucleotidase (5NT)/CD73