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In the acute phase of colitis in trinitrobenzene-sulfonic acid (TNBS)-induced mouse model of intestinal inflammation, a decrease in the level of FAAH mRNA was observed in inflamed region of colon, while in the late phase of inflammation, the level of FAAH was increased

This approach emerged pragmatically from research schedules but aligns well with receptor recovery kinetics and avoids the potential tolerance development that continuous daily dosing over many weeks might produce

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Tayran H, Yilmaz E, Bhattarai P et al (2024b) ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimers disease through BDNF/NGFR signaling